Monash University

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Reason: Under embargo until 27 February 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.

Elucidating new mechanisms controlling the responses induced by the innate immune receptor Stimulator of Interferon Genes (STING)

posted on 2023-02-01, 06:12 authored by KATHERINE ROSE BALKA
The immune receptor STING is crucial for detecting microbial infections and mounting an immune response via the production of inflammatory mediators. However, inappropriate STING activation is linked to several diseases including, autoimmune and neuroinflammatory conditions. This thesis better defines several new key aspects of STING responses, including a clearer understanding of the molecular mechanisms controlling inflammation, as well as how STING responses are shut off to prevent chronic inflammation. Understanding STING function is important for effective targeting of this pathway for disease prevention.


Principal supervisor

Dominic Denardo

Additional supervisor 1

Meredith O'Keeffe

Additional supervisor 2

Benjamin Kile

Year of Award


Department, School or Centre

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses