Elaboration of Acylsulfonohydrazides into Selective Tools to Probe MYST HAT Function

Acute myeloid leukemia (AML) is a type of bone marrow cancer, with a low survival rate, and leukemia stem cells (LSC) is a major factor in the development of AML. Histone acetyltransferase (HAT) enzymes are essential for a wide range of normal cellular processes, including cell proliferation and DNA replication. Specifically, two HAT enzymes, MOZ and HBO1, have been identified as critical regulators for the maintenance of LSC. My project is focused on the synthesis, and biological testing of small drug molecules to inhibit MOZ and HBO1 as epigenetic targets, as a potential treatment for AML and other chronic diseases.