Monash University
Christie thesis final 240619.pdf (1.83 MB)

Effect of Pre-maturation of Immature Oocyte with a C-type Natriuretic Peptide (CNP) on Maturation and Subsequent Embryo Production from Unstimulated Mice

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posted on 2019-07-05, 03:53 authored by CHRISTIE LEE SUN
In vitro maturation (IVM) is a promising assisted reproductive technology for human infertility treatment. However, the developmental outcomes are poorer compare to in vitro fertilisation with hormone stimulation. Women with advanced maternal age are prone to have poor response to the stimulation. This thesis examines the effects of two-step IVM with addition of C-type natriuretic peptide at different time points on young and aging mice, in order to improve the oocyte maturation and embryo development. It is suggested that when conventional IVM works well, small differences in cytoplasmic and nuclear synchrony may not have significant impact overall, using unstimulated animals.


Principal supervisor

Mulyoto Pangestu

Additional supervisor 1

Sally Catt

Additional supervisor 2

Kiri Beilby

Year of Award


Department, School or Centre

Clinical Sciences at Monash Health

Additional Institution or Organisation

Obstetrics and Gynaecology

Campus location



Master of Reproductive Sciences

Degree Type



Faculty of Medicine Nursing and Health Sciences