Christie thesis final 240619.pdf (1.83 MB)
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Effect of Pre-maturation of Immature Oocyte with a C-type Natriuretic Peptide (CNP) on Maturation and Subsequent Embryo Production from Unstimulated Mice

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thesis
posted on 05.07.2019, 03:53 by CHRISTIE LEE SUN
In vitro maturation (IVM) is a promising assisted reproductive technology for human infertility treatment. However, the developmental outcomes are poorer compare to in vitro fertilisation with hormone stimulation. Women with advanced maternal age are prone to have poor response to the stimulation. This thesis examines the effects of two-step IVM with addition of C-type natriuretic peptide at different time points on young and aging mice, in order to improve the oocyte maturation and embryo development. It is suggested that when conventional IVM works well, small differences in cytoplasmic and nuclear synchrony may not have significant impact overall, using unstimulated animals.

History

Principal supervisor

Mulyoto Pangestu

Additional supervisor 1

Sally Catt

Additional supervisor 2

Kiri Beilby

Year of Award

2019

Department, School or Centre

Obstetrics and Gynaecology

Campus location

Australia

Course

Master of Reproductive Sciences

Degree Type

MPHIL

Faculty

Faculty of Medicine Nursing and Health Sciences

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