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Early developmental biology of the spiny mouse (Acomys cahirinus)

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thesis
posted on 14.03.2019 by JARED PETER MAMROT
The spiny mouse is a small rodent that displays remarkable physiological traits: they can regenerate skin without scarring, they have a human-like hormone profile, and they are the only known rodent with a menstrual cycle. During my PhD I explored early development in this species. I assembled a reference transcriptome and mapped gene expression during the 2-cell, 4-cell and 8-cell stages of embryo development. Ultimately, I found that the spiny mouse is a more accurate model of human embryo development in the earliest stages compared to lab mice. This work provides novel insight into the biological mechanisms that govern the creation of new life.

History

Principal supervisor

Hayley Dickinson

Additional supervisor 1

David W. Walker

Additional supervisor 2

David K. Gardner

Additional supervisor 3

Mulyoto Pangestu

Year of Award

2018

Department, School or Centre

Obstetrics and Gynaecology

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports