L121 Jared_Mamrot_PhD_thesis_Redacted.pdf (23.42 MB)
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Early developmental biology of the spiny mouse (Acomys cahirinus)

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posted on 14.03.2019, 04:37 by JARED PETER MAMROT
The spiny mouse is a small rodent that displays remarkable physiological traits: they can regenerate skin without scarring, they have a human-like hormone profile, and they are the only known rodent with a menstrual cycle. During my PhD I explored early development in this species. I assembled a reference transcriptome and mapped gene expression during the 2-cell, 4-cell and 8-cell stages of embryo development. Ultimately, I found that the spiny mouse is a more accurate model of human embryo development in the earliest stages compared to lab mice. This work provides novel insight into the biological mechanisms that govern the creation of new life.


Principal supervisor

Hayley Dickinson

Additional supervisor 1

David W. Walker

Additional supervisor 2

David K. Gardner

Additional supervisor 3

Mulyoto Pangestu

Year of Award


Department, School or Centre

Obstetrics and Gynaecology

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences