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EFFECTS OF P-REX1 OVEREXPRESSION ON MAMMARY DEVELOPMENT AND CANCER

thesis
posted on 30.01.2020, 02:32 by NUTHASUDA SRIJAKOTRE
P-Rex1 is a protein which show negligible expression in normal breast tissue but is upregulated in the luminal subtype of breast cancer. This thesis examined the effects of increased P-Rex1 expression in mammary epithelial cells of mice and demonstrated that P-Rex1 can play a causal role in driving mammary tumour development. Furthermore, expression of P-Rex1 in the mammary gland of a mouse model of breast cancer increased mammary tumour incidence and metastasis. These findings provide in vivo evidence that P-Rex1 plays an oncogenic role in breast cancer and suggest that targeting P-Rex1-regulated molecular signalling pathways may offer therapeutic benefits.

History

Principal supervisor

Christina Anne Mitchell

Additional supervisor 1

Lisa Ooms

Year of Award

2020

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

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