Monash University

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Dynamic infection models, metabolomics and mechanism-based modelling to investigate pharmacodynamic challenges of Pseudomonas aeruginosa

posted on 2023-03-22, 23:36 authored by JESSICA ROSE TAIT
The bacterial species known as Pseudomonas aeruginosa is a major cause of life-threatening infections in critically ill patients and patients with cystic fibrosis. The characteristics of this bacterium mean it can evade the effect of antibiotics, particularly when they are administered in a sub-optimal manner. Analysis of the relationship between antibiotic exposure and bacterial response over a time-course is essential in the development of new treatment approaches. In this thesis, clinically available antibiotics were tested, alone and in combination, against P. aeruginosa clinical isolates over time to identify rationalised antibiotic combination regimens.


Campus location


Principal supervisor

Cornelia Barbara Landersdorfer

Additional supervisor 1

Darren J Creek

Year of Award


Department, School or Centre

Drug Delivery, Disposition and Dynamics


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences