RetamalSantibanez_Final thesis.pdf (39.37 MB)
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Drug Delivery Systems for Advanced Treatment of Pain and Inflammation

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thesis
posted on 06.05.2022, 00:59 by JEFFRI STEVENS RETAMAL SANTIBANEZ
The main focus of this thesis is to understand how the signalling of GPCRs can influence cellular processes of relevance to pain and inflammation, in a spatiotemporal manner. Two key receptors in pain pathways, including the Neurokinin 1 Receptor and metabotropic glutamate receptor mGlu5, were investigated to assess how these GPCRs contribute to signalling when distributed to endosomes; and if endosomal signalling can be targeted to modulate pain. The thesis utilises genetic encoded biosensors, pharmacological tools and polymeric nanoparticles for location-specific drug delivery. An additional study investigated the importance of the ion channel TRPV4 as an effector protein for serotonin-induced 5HT2A receptor signalling and edema. This thesis includes 3 results chapters and 2 manuscripts published in peer reviewed journals. The main project of this thesis is an unpublished chapter studying the role of mGlu5 endocytosis for pain transmission.

History

Campus location

Australia

Principal supervisor

Nicholas Veldhuis

Additional supervisor 1

Daniel Poole

Additional supervisor 2

Karen Gregory

Additional supervisor 3

Thomas Davis

Year of Award

2022

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

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