Monash University

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Reason: Under embargo until November 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Drug Delivery Systems Derived from Porous Silicon and Polymers for Cancer Treatments

posted on 2019-11-02, 11:47 authored by DEXIANG ZHANG
Chemotherapy is used extensively for inhibiting the growth of tumors or reducing tumor size. However, most of the potential and existing drugs are poorly water soluble, which greatly limits their practical application. In this thesis, effects were made to develop new drug delivery systems from porous silicon nanomaterials and polymers for cancer treatments. The hydrophobic camptothecin was chosen as a model anticancer drug. Due to the pore confinement of nanomaterials, drug solubility could be improved and sustained drug release was achieved. Porous silicon incorporated with polymer and active targeting peptide could maintain colloidal stability and enhance cell killing.


Campus location


Principal supervisor

Nicolas Hans Voelcker

Additional supervisor 1

Helmut Thissen

Year of Award


Department, School or Centre

Drug Delivery, Disposition and Dynamics


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences