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Discovery & Design of Novel DsbA Inhibitors Using Fragment-Based Design Strategies
thesisposted on 18.02.2020, 06:27 by WESAM SHALAN ALWAN ALWAN
In this work, Wesam designed and synthesised compounds to overcome multi-drug resistant bacteria and potentially protect future antibiotics from becoming obsolete. This was done by investigating a novel mechanism of disarming bacteria thereby making them unable to cause infections, rather than killing bacteria. The project focussed on using fragment-based drug design to develop inhibitors of a bacterial protein that is a master regulator of bacterial virulence.