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Direct and indirect inhibition of kallikrein family proteases

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thesis
posted on 2019-06-04, 06:23 authored by BLAKE RILEY
Kallikreins are enzymes involved in many diseases, including prostate cancer and a variety of skin disorders — blocking their activity can treat these diseases. This thesis examines mechanisms of inhibition within kallikreins, and how an inhibitor molecule from sunflower seeds works, laying the groundwork for future drug development.

History

Principal supervisor

Ashley Buckle

Additional supervisor 1

Sheena McGowan

Year of Award

2019

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences