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Development of recombinant multiepitope proteins-based point of care test diagnosis for multiple sexual transmitted diseases in humans
thesisposted on 11.02.2020, 12:31 by RAGUL PARAMASIVAM
This research aims to performed systematic review to assess the diagnostic accuracy of all reported recombinant antigens and multiple point-of-care rapid assay platforms for Chlamydia, Gonorrhea, Syphilis, Herpes, Acquired Immune Deficiency Syndrome and Hepatitis B detection according to standard methods and summarise test performance using meta-analysis to identify promising antigen for development of multiepitopic peptide for detection of Chlamydia, Gonorrhea, Syphilis, Herpes, Acquired Immune Deficiency Syndrome and Hepatitis B antigen and antibodies. Further to develop indirect IgG and IgM ELISA, Lateral flow rapid assay and IgM and IgG piezoelectric QCM diagnostic assay to detect STIs antibodies using multiepitopic peptides (MEP).