Monash University

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Reason: Under embargo until November 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Development of novel compounds for inhibition of pro-inflammatory C-reactive protein and investigation into shear-induced CRP dissociation

posted on 2020-11-22, 22:57 authored by JULIA LOSEFF-SILVER
C-reactive protein (CRP) is a protein involved in the immune response during infection and inflammation. However, in cardiovascular diseases (CVD), especially myocardial infarction and stroke, CRP can induce overshooting inflammatory responses contributing to increased infarct size or even death. With the aim to create a drug to prevent CRP from triggering overshooting inflammatory reactions during CVD, in this thesis I tested two generations of small molecules designed to stop CRP pro-inflammatory effects. Moreover, we discovered that circulating blood exposed to high shear stress as in patients with stenosed heart valves or blood vessels stenosed by atherosclerosis, causes CRP to be strongly pro-inflammatory, subjecting those patients to higher risk of cardiovascular events.


Principal supervisor

Karlheinz Peter

Additional supervisor 1

Alex Bobik

Year of Award


Department, School or Centre

Clinical Sciences at Monash Health

Additional Institution or Organisation


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences