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Development of Quartz Crystal Microbalance-Based Biosensors for Detection of Infectious Diseases
thesis
posted on 2023-01-03, 00:55 authored by Hui Jean LimA simple and versatile surface functionalisation method employing molecularly imprinted polydopamine (MIPDA) sensing films was developed for the detection of infectious diseases via quartz crystal microbalance (QCM)-based biosensors. Recognition cavities in the MIPDA films provided QCM-based biosensors with a selective affinity towards specific viral antigens. The biosensor responses were enhanced by increasing the density of recognition cavities via film thickness optimisation and site-specific imprinting of the viral antigen. The MIPDA-QCM biosensing technique could detect and quantitate clinically relevant concentrations of hepatitis B and dengue virus antigens within 10 min, providing a rapid and single-step detection procedure for point-of-care disease diagnosis.
