Monash University

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Reason: Under embargo until December 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing

Development of Quartz Crystal Microbalance-Based Biosensors for Detection of Infectious Diseases

posted on 2023-01-03, 00:55 authored by Hui Jean Lim
A simple and versatile surface functionalisation method employing molecularly imprinted polydopamine (MIPDA) sensing films was developed for the detection of infectious diseases via quartz crystal microbalance (QCM)-based biosensors. Recognition cavities in the MIPDA films provided QCM-based biosensors with a selective affinity towards specific viral antigens. The biosensor responses were enhanced by increasing the density of recognition cavities via film thickness optimisation and site-specific imprinting of the viral antigen. The MIPDA-QCM biosensing technique could detect and quantitate clinically relevant concentrations of hepatitis B and dengue virus antigens within 10 min, providing a rapid and single-step detection procedure for point-of-care disease diagnosis.


Campus location


Principal supervisor

Ooi Chien Wei

Additional supervisor 1

Tridib Saha

Additional supervisor 2

Tey Beng Ti

Year of Award


Department, School or Centre

School of Engineering (Monash University Malaysia)


Doctor of Philosophy

Degree Type



Faculty of Engineering