Final Thesis_Uttam Dutta - Zeljka Abaza.pdf (19.25 MB)
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Development of Highly Regioselective Functionalizations of Arenes, Heteroarenes and Alkynes

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thesis
posted on 04.08.2020, 02:02 authored by Uttam Dutta
Innovation and implementation of science and technology are the key parameter to define the socio-economic background of a nation. In the realm of modern chemical science, complexity of the biologically active molecules and the underlying mechanistic intricacies fascinated the synthetic chemists over the centuries. Structurally C−H and C−C bonds are the fundamental backbone of organic molecules. Hence, the expansion of synthetic scope of organic chemistry is largely dependent on devising a suitable protocol in a simple and environmentally binging way. The work presented in this thesis, entitled as “Development of Highly Regioselective Functionalizations of Arenes, Heteroarenes and Alkynes” describes the regioselective functionalizations of C−H and C−C bonds. In one part, the reactions have been devised relying on radical based metal free approaches, on the other hand, to accomplish highly regioselective transformations, a prudent combinations of transition metals, ligands, oxidants and template have been designed. In this regard, an unprecedented selective distal arene-meta and para-C−H bond has been functionalized using a preinstalled director.

History

Principal supervisor

D. Maiti

Additional supervisor 1

David W. Lupton

Year of Award

2018

Department, School or Centre

School of Chemistry

Additional Institution or Organisation

Indian Institute of Technology, Bombay (IITB)

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Science