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Development of Foldamers for Peptide Receptor Radionuclide Therapy of NPY1 Tumours

thesis
posted on 2024-05-01, 23:58 authored by AMIT HETSRON
This thesis develops a novel targeted radioactive therapy for breast cancer (BC) using theranostics. A theranostic agent is a compound that can carry a diagnostic or therapeutic radioisotope capable of precisely targeting tumours, allowing clinicians to see what they treat. Specifically, we developed first-in-class potent theranostic agent, which is stable in the blood stream. Our results demonstrate successful imaging of the targeted receptor in mice, potentially leading to clinical translation and improving diagnostics and treatment outcomes for BC patients.

History

Campus location

Australia

Principal supervisor

Philip Thompson

Additional supervisor 1

Mo Haskali

Year of Award

2024

Department, School or Centre

Medicinal Chemistry

Additional Institution or Organisation

Peter MacCallum Cancer Centre

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences