Development of Fluorescent and Photoactivatable Ligands Targeting the Dopamine D2 Receptor

The dopamine D2 receptor is the primary target for antipsychotic agents and the treatment of schizophrenia, and plays an established role in the therapy of Parkinson’s disease. This thesis fills the gap of chemical tools for studying the D2R by developing several series of fluorescent and photoactivatable ligands that can be used to probe the D2R structure and associated pharmacology.