Development of Calcium-sensing receptor (CaSR) positive allosteric modulators for the treatment of CaSR-related disorders

The calcium-sensing receptor, ubiquitously expressed in the body, is an important target endocrine and calcium handling disorders such as hyperparathyroidism. Current therapeutics for hyperparathyroidism and related disorders are often accompanied by undesirable side effects, which limit their clinical utility. Therefore, there is a need for better therapeutics targeting the CaSR. As the CaSR continues to find application in other diseases, developing tool compounds for the receptor to better design drug molecules become crucial. Hence, this study endeavours to gain better insights by probing the CaSR with tool compounds and focuses on developing new therapeutic candidates targeting the CaSR.