Embargoed and Restricted Access
Reason: Under embargo until 30 November 2026. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Development of CXCR1/2 BsAb for the treatment of solid tumors
thesis
posted on 2023-11-30, 11:36 authored by FARNAZ FAHIMIThis study focused on countering immune evasion in cancer treatment by targeting myeloid-derived suppressor cells (MDSCs) using a novel bispecific antibody against CXCR1 and CXCR2 receptors. The research involved developing the antibody, confirming its accuracy and reactivity, and testing its inhibitory effect on MDSC recruitment. In mouse models, the antibody was combined with an anti-PD1 antibody in two tumor types. In triple-negative breast cancer, a significant decrease in tumor size was observed alongside reduced MDSCs, leading to improved T cell infiltration. This study offers a promising strategy to enhance cancer immunotherapy by reshaping the tumor microenvironment.
