Development of Biosensing Nanoparticles using Organosilica

Detection and monitoring of proteins and metabolites in tissues, organs and blood represents a grand challenge in the field of sensing, because blood sampling does not necessarily reflect tissue biochemistry. The development of responsive nanomaterials that retain stability and function in biological environments is therefore an area of significant importance. This thesis describes the synthesis and characterisation of specialised nanoparticles for dynamic monitoring in challenging environments. This technology has the potential to provide data to guide disease treatment in a real-time and continuous manner.