Development and in vivo/in vitro evaluation of A novel NEBULIZER

This thesis aims to develop a cost-effective and disposable drug delivery nebulizer that is used for the treatment of chronic obstructive pulmonary disease and bronchial asthma, as well as establish the correlation between in vitro and in vivo tests for inhalation preparation. In this study, the best combination of structural parameters has been determined based on the simulation and experimental results, and a nebulizer suitable for inhalation suspension drug delivery has been successfully designed. A good correlation between in vitro and in vivo data of inhaled preparations has been achieved, which can predict the plasma concentration of the proposed drugs. Through these relationships, the development of inhalation devices and drugs can directly determine the structural design on the basis of the outputs of simulations or experiments with bionic platforms, which can save significant investment in clinical trials.