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Development and Testing of Nanoparticle Vaccines for Influenza and COVID-19

thesis
posted on 02.08.2022, 23:45 authored by NGOC MAI VU

Vaccination has proven to be one of the most successful public health interventions. However, new vaccine design approaches are essential to counter infectious diseases which have defied conventional vaccination efforts. Nanoparticle vaccines that enable the elicitation of strong and broad immunity offer great opportunities to supplement traditional vaccines, providing tractable solutions to combat dangerous pathogens. Here, we successfully prepared improved nanoparticle vaccines for influenza and COVID-19 and gained greater insights into immunological mechanisms that drove immunogenicity of nanoparticle vaccines in mice. This work could facilitate rational design of next-generation vaccines and pave the way for further advances in vaccine nanotechnology.

History

Campus location

Australia

Principal supervisor

Nghia Truong Phuoc

Additional supervisor 1

Thomas Davis

Additional supervisor 2

Stephen Kent

Additional supervisor 3

Adam Wheatley

Year of Award

2022

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Additional Institution or Organisation

Peter Doherty Institute for Infection and Immunity, Department of Microbiology and Immunology, UoM

Course

Doctor of Philosophy

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences