Developing the therapeutic potential of Semaphorin 5A in human glioblastomas.

Glioblastomas are the most deadly form of brain cancers due to their high invasiveness and resistance to chemo- and radiotherapy. High tumor recurrence and the lack of effective treatments result in poor patient survival of 12-16 months. In this study, the therapeutic potential of a novel tumor suppressor protein Semaphorin 5A was established by successful identification of its minimal region that confers potent effect in counteracting cancer cell proliferation, invasion and tumor formation. These findings pave the way to develop Sema5A into a promising therapeutic agent against brain cancers.