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Reason: Under embargo until 13 June 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.

Developing safe and immune-tolerated cell-based therapies for the treatment of multiple sclerosis

thesis
posted on 2023-03-17, 04:29 authored by Xiaoxue Ma

Stem cell-based regenerative medicine is rapidly advancing, however, the risk of tumor formation and immune rejection of foreign grafts remain as major hurdles hindering clinical translation. Our laboratory has previously addressed these issues by developing a kill switch termed the SafeCell System to eliminate tumorigenic cells from a graft, and the induced Allogeneic Cell Tolerance (iACT) System to allow ‘universal’ acceptance of cells. Here, we tested the SafeCell and iACT systems following transplantation of cells into the mouse brain, thereby validating their potential application for treating neurological diseases. As a means to more effectively treat multiple sclerosis MS, we created designer cells that express an inducible therapeutic protein, interleukin 1 receptor 2 (IL-1R2). IL-1R2 produced by therapeutic cells showed anti-inflammatory properties, blocking the production of an immune cell type that promotes tissue damage in MS

History

Principal supervisor

Andras Nagy

Additional supervisor 1

Natalie Payne

Year of Award

2022

Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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