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Reason: Under embargo until May 2024. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.

Developing novel bacteriophage-antibiotic combination therapy against multidrug-resistant Klebsiella pneumoniae

thesis
posted on 2023-05-23, 22:49 authored by BABITA KUMARI
Antibiotic resistance is a global health threat and effective alternatives are urgently need to treat critical nosocomial pathogens including Klebsiella pneumoniae. A promising strategy that is gaining popularity is the use of bacteriophages (phages). However, emergence of resistance to phages is rapid and combination of phages with antibiotics has been increasingly investigated. In this study, new phages were isolated and characterised, and their combination with antibiotics was evaluated to reduce the resistance and maximise bacterial killing in vitro and in vivo. Mechanisms underpinning phage resistance were examined using genome sequencing and molecular microbiology. The mechanistic findings of enhanced bacterial killing with phage-ceftazidime/avibactam combination provide important information for treating critically-ill patients with multidrug-resistant K. pneumoniae infections. This PhD project will contribute to the development of effective phage therapy in clinic.

History

Principal supervisor

Jian Li

Additional supervisor 1

Dr Sue Nang

Additional supervisor 2

Dr Mohammad Azad

Year of Award

2023

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Microbiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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