Monash University
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Developing iPSC-derived off-the-shelf therapies for restoring thymus function in immunodeficiency.

thesis
posted on 2024-10-10, 17:23 authored by Rachelle Jayne Duffin
A characteristic feature of most, if not all, cancer patients is that they are immune suppressed, in part due to a marked loss in T cells. This immunodeficiency results from a combination of factors including, chemotherapy and natural the ageing processes which deplete thymus function. The thymus is an immune organ where T cells develop. Without a functioning thymus, patients are susceptible to cancer relapse and infection. This project focused on restoring thymus function in immunodeficient models using T cell progenitors generated from human stem cells.

History

Principal supervisor

Alan Trounson

Year of Award

2024

Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences