Monash University

Embargoed and Restricted Access

Reason: Under embargo until 30 December 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.

Determining the role of maternal epigenetic inheritance in offspring brain development and behaviour

posted on 2022-12-12, 22:33 authored by SIGRID ROMY PETAUTSCHNIG
Eggs and sperm carry genetic information that is inherited by offspring from their parents. Non-genetic (epigenetic) information is also passed from parents and can influence offspring health and development. Remarkably, this epigenetic information can be influenced by environmental agents, such as parental diet or drug intake, but the mechanisms involved are not well understood. This project explored how epigenetic changes in a mother’s egg impact brain development and behaviour in offspring and identified a new mechanism that affects inherited behavioural outcomes. The outcomes extend our understanding of inherited disease and rare human congenital abnormalities that have an epigenetic basis.


Principal supervisor

Patrick Stephen Western

Additional supervisor 1

Maarten van den Buuse

Year of Award


Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Molecular and Translational Science (Hudson Institute)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences