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Determining the role of maternal epigenetic inheritance in offspring brain development and behaviour
thesisposted on 2022-12-12, 22:33 authored by SIGRID ROMY PETAUTSCHNIG
Eggs and sperm carry genetic information that is inherited by offspring from their parents. Non-genetic (epigenetic) information is also passed from parents and can influence offspring health and development. Remarkably, this epigenetic information can be influenced by environmental agents, such as parental diet or drug intake, but the mechanisms involved are not well understood. This project explored how epigenetic changes in a mother’s egg impact brain development and behaviour in offspring and identified a new mechanism that affects inherited behavioural outcomes. The outcomes extend our understanding of inherited disease and rare human congenital abnormalities that have an epigenetic basis.
Principal supervisorPatrick Stephen Western
Additional supervisor 1Maarten van den Buuse
Year of Award2022
Department, School or CentreCentral Clinical School
Additional Institution or OrganisationMolecular and Translational Science (Hudson Institute)
CourseDoctor of Philosophy
FacultyFaculty of Medicine, Nursing and Health Sciences