File(s) under embargo

25

day(s)

until file(s) become available

Determination of the ligand pharmacophore required for secondary conformation activation of the human Beta1-adrenoceptor

thesis
posted on 25.11.2020, 23:33 by Emanuel Pinto De Sousa
This thesis aims to better understand at the cellular level the behaviour of beta-blockers, which decrease the heart rate and are used daily in the treatment of cardiovascular diseases and anxiety. Some medicines in this class can both decrease and increase the heart rate depending on the amount used. To study this, we developed new molecules based on a known beta-blocker with this effect and evaluated their behaviour in cell lines. We identified molecular features that modulate this peculiar effect. In future, the understanding of this behaviour may contribute to an improved profile of beta-blockers leading to less side effects.

History

Campus location

Australia

Principal supervisor

Peter Scammells

Additional supervisor 1

Shailesh Mistry

Additional supervisor 2

Jillian Baker

Year of Award

2020

Department, School or Centre

Medicinal Chemistry

Additional Institution or Organisation

The University of Nottingham

Course

Doctor of Philosophy (Joint Award and Doctoral Training Centre with The University of Nottingham)

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Usage metrics

Licence

Exports