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Detection and treatment strategies for influenza viruses with reduced susceptibility to baloxavir marboxil

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posted on 2022-06-23, 05:30 authored by PAULINA ALICJA KOSZALKA

 Viruses with resistance to an antiviral drug limit the treatment options for ill patients and may circulate globally and cause widespread resistance. This thesis examines influenza viruses that are resistant to the antiviral drug baloxavir marboxil. First we developed detection methods to identify influenza viruses with baloxavir resistance. We then studied the impact of baloxavir resistance on how effective antiviral treatment was in the ferret model. Finally, we used mathematical modelling to estimate the impact of antiviral treatment of influenza and drug resistant viruses at a population scale. 

History

Principal supervisor

Stephen Turner

Additional supervisor 1

Kanta Subbarao

Additional supervisor 2

Aeron Hurt

Additional supervisor 3

Vijay Dhanasekaran

Year of Award

2022

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Microbiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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