Monash University

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Reason: Under embargo until August 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Designing a tissue-selective steroidal mineralocorticoid receptor antagonist for the treatment of chronic heart failure

posted on 2020-08-18, 03:59 authored by AMANPREET KAUR
This thesis investigated a novel approach to design a drug that binds selectively to the cardiac tissue and spare the kidneys. This drug is aimed at treating chronic heart failure patients. The findings of the thesis suggested that a drug could be designed so when it reaches the heart, it binds to the targeted receptor. However, upon entering kidneys, the drug can be inactivated by an enzyme that is specifically present in the kidney and absent in the heart.


Campus location


Principal supervisor

Jonathan Baell

Additional supervisor 1

Morag Young

Year of Award


Department, School or Centre

Medicinal Chemistry


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences