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Design, synthesis and pharmacological evaluation of novel fluorescent ligands for the mu-opioid receptor

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thesis
posted on 16.02.2022, 05:22 by William Marshall
There are increasing reports in the literature suggesting that the Mu-opioid receptor (MOR) is overexpressed in several human malignancies. This has led to the hypothesis that there is an association between peripheral MOR expression and tumour progression. Of particular concern is that MOR agonists are routinely used in cancer patients to control pain, through activation of central MORs, but also activate peripheral MORs (leading to undesirable effects). It is therefore important to investigate how different ligands influence tumour progression through interaction with peripheral and central opioid receptors. This project focuses on the design, synthesis and pharmacological characterisation of novel fluorescent opioid receptor ligands, as tools to investigate this phenomenon further.

History

Principal supervisor

Peter Scammells

Additional supervisor 1

Barrie Kellam

Additional supervisor 2

Shailesh Mistry

Additional supervisor 3

Steve Hill

Year of Award

2021

Department, School or Centre

Monash Institute of Pharmaceutical Sciences

Additional Institution or Organisation

University of Nottingham

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

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