THESIS MASTER - v3.7 corrections_L74.pdf (10.72 MB)
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Design and evaluation of fluorescent and non-fluorescent bivalent ligands to explore their mode of action at neuropeptide Y receptors

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thesis
posted on 05.06.2019, 06:45 by Rachel Roseanne Richardson
This thesis describes the design and synthesis of novel fluorescent and non-fluorescent derivatives of the cyclic peptide GR231118 and the study of their actions at the Y1 and the Y4 receptors. A refined understanding of the molecular mechanism of peptide binding to the receptors was obtained. The effect of GR231118 treatment on receptor organisation at the cell membrane was also investigated. Results indicate that treatment with the dimer GR231118 peptide leads to Y1 receptor clustering. Collectively, the thesis improves understanding of the Y1 and Y4 receptor pharmacology which will lead the development of new therapeutic approaches in several diseases.

History

Campus location

Australia

Principal supervisor

Philip Thompson

Additional supervisor 1

Nicholas Holliday

Additional supervisor 2

Stephen Briddon

Additional supervisor 3

Charles Laughton

Year of Award

2019

Department, School or Centre

Medicinal Chemistry

Additional Institution or Organisation

University of Nottingham, UK

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

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