Embargoed and Restricted Access
Reason: Under embargo until 31 January 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Design and Synthetic Investigations toward pH-Sensitive Dual-Release Molecular Frameworks
thesis
posted on 2022-02-16, 22:52 authored by YAYAO ZHOUThe aim of this thesis is to enable incorporation of a dually-functionalized molecular apparatus that can be assembled within a nanoparticle for selective and controlled release of both payloads in the acidic environment of a solid tumour. For proof of concept, a variety of acylhydrazone-based dual release molecular frameworks are designed and synthesized, and their hydrolytic stability are tested at various pH values. We successfully obtain a diverse set of novel linkers with different scaffolds that can undergo rapid cleavage and dual payload release in fine increments from pH 4.5 all the way to pH 7.4.
