Monash University

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Reason: Under embargo until 31 January 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing

Design and Synthetic Investigations toward pH-Sensitive Dual-Release Molecular Frameworks

posted on 2022-02-16, 22:52 authored by YAYAO ZHOU
The aim of this thesis is to enable incorporation of a dually-functionalized molecular apparatus that can be assembled within a nanoparticle for selective and controlled release of both payloads in the acidic environment of a solid tumour. For proof of concept, a variety of acylhydrazone-based dual release molecular frameworks are designed and synthesized, and their hydrolytic stability are tested at various pH values. We successfully obtain a diverse set of novel linkers with different scaffolds that can undergo rapid cleavage and dual payload release in fine increments from pH 4.5 all the way to pH 7.4.


Campus location


Principal supervisor

Jonathan Baell

Additional supervisor 1

Francesca Ercole

Year of Award


Department, School or Centre

Medicinal Chemistry


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences