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Design and Exploration of Sphingolipid Mimetics in Lipid Metabolism

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posted on 2024-10-25, 06:26 authored by MUN CHUNG DOROTHY KO
In this project we designed and made medicine-like molecules that mimic the sphingolipids to determine whether the modulation of sphingolipids can treat metabolic disease-associated fatty liver disease. These molecules were tested in a representative cell-based fatty liver model we developed to screen for lipid lowering effects. These efforts have uncovered a new class of molecule which modulates sphingolipids and independently reduces lipid levels in liver cells. Overall, this work has lead to the discovery of a new potential medicine class which has the potential to treat MAFLD through two independent modes.

History

Campus location

Australia

Principal supervisor

Bernard Flynn

Additional supervisor 1

Dr. Sarah Turpin-Nolan

Year of Award

2024

Department, School or Centre

Medicinal Chemistry

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

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    Faculty of Pharmacy and Pharmaceutical Sciences Theses

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