Monash University

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Reason: Under embargo until June 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Design, Synthesis, and Investigation of pH-sensitive Linkers as Potential Cytotoxic Delivery Moieties

posted on 2019-06-24, 03:46 authored by JEPHTHAH OKOLIKO ODIBA
Pro-survival BCL-XL proteins have been previously reported to be a promising target for cancer drug therapy, as they are widely expressed in various malignancies. This thesis describes the synthesis of effective chemical entities designed to inhibit these proteins and treat cancer cells. However, platelet toxicity has restricted their progression into the clinical phase. In addition, we sought out to developed and investigate potential pH-responsive moieties as delivery carriers towards the selective targeting of solid tumours and to render this conjugate unavailable to platelets (platelets toxicity).


Campus location


Principal supervisor

Jonathan Baell

Additional supervisor 1

Dr. Nghi Nguyen

Additional supervisor 2

Prof. Thomas Davis

Additional supervisor 3

Dr. Francesca Ercole

Year of Award


Department, School or Centre

Medicinal Chemistry


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences