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Delivery of pDNA using lipid nanoparticles: impact of lipid composition, molar ratio, and route of administration

thesis
posted on 15.02.2021, 10:44 by Azizah Algarni
Lipid nanoparticle (LNP) is a promising non-viral nanocarrier for in-vivo delivery of nucleic acids into cells. However, LNPs have been extensively optimised for siRNA delivery and it remains unclear whether such optimum LNP formulations can also deliver pDNA effectively. In this thesis, I aimed to elucidate the influence of lipid composition and physicochemical properties of LNPs and the effect of administration routes on pDNA delivery efficiency. The outcomes revealed important new knowledge that can serve as a guideline for the development of next-generation LNPs for highly efficient pDNA delivery.

History

Campus location

Australia

Principal supervisor

Nghia Truong Phuoc

Additional supervisor 1

Colin Pouton

Year of Award

2021

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Course

Master of Philosophy

Degree Type

MPHIL

Exports