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Delivery of pDNA using lipid nanoparticles: impact of lipid composition, molar ratio, and route of administration
thesisposted on 15.02.2021, 10:44 by Azizah Algarni
Lipid nanoparticle (LNP) is a promising non-viral nanocarrier for in-vivo delivery of nucleic acids into cells. However, LNPs have been extensively optimised for siRNA delivery and it remains unclear whether such optimum LNP formulations can also deliver pDNA effectively. In this thesis, I aimed to elucidate the influence of lipid composition and physicochemical properties of LNPs and the effect of administration routes on pDNA delivery efficiency. The outcomes revealed important new knowledge that can serve as a guideline for the development of next-generation LNPs for highly efficient pDNA delivery.