Monash University

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Reason: Under embargo until February 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Delivery of pDNA using lipid nanoparticles: impact of lipid composition, molar ratio, and route of administration

posted on 2021-02-15, 10:44 authored by Azizah Algarni
Lipid nanoparticle (LNP) is a promising non-viral nanocarrier for in-vivo delivery of nucleic acids into cells. However, LNPs have been extensively optimised for siRNA delivery and it remains unclear whether such optimum LNP formulations can also deliver pDNA effectively. In this thesis, I aimed to elucidate the influence of lipid composition and physicochemical properties of LNPs and the effect of administration routes on pDNA delivery efficiency. The outcomes revealed important new knowledge that can serve as a guideline for the development of next-generation LNPs for highly efficient pDNA delivery.


Campus location


Principal supervisor

Nghia Truong Phuoc

Additional supervisor 1

Colin Pouton

Year of Award


Department, School or Centre

Drug Delivery, Disposition and Dynamics


Master of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences