Monash University

Embargoed and Restricted Access

Reason: Under embargo until June 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Delivery of Anti Cancer Drugs to Breast Cancer Cells using pH-sensitive Inorganic Nanoparticles

posted on 2020-07-10, 03:20 authored by FITYA SYARIFA MOZAR
pH-sensitive inorganic nanoparticles have shown enormous potential as chemotherapeutic drug delivery carriers. Three different nanocrystals namely carbonate apatite (CA), strontium sulfite (SrSO3), and strontium fluoride (SrF2) were fabricated in this study and subsequently delivered to breast cancer cells after incorporation with selected anticancer drugs. These treatment effectivities were assessed both in vitro using human and mice breast cancer cell lines, as well as in vivo using tumor-bearing mice models. Biodegradability, versatility, cost-effective and easy fabrication technique gives these nanocrystals marked advantages compared to other conventional nanoparticles.


Principal supervisor

Ezharul Hoque Chowdhury

Additional supervisor 1

Rakesh Naidu

Year of Award


Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences