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Reason: Under embargo until June 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Delivery of Anti Cancer Drugs to Breast Cancer Cells using pH-sensitive Inorganic Nanoparticles
thesisposted on 2020-07-10, 03:20 authored by FITYA SYARIFA MOZAR
pH-sensitive inorganic nanoparticles have shown enormous potential as chemotherapeutic drug delivery carriers. Three different nanocrystals namely carbonate apatite (CA), strontium sulfite (SrSO3), and strontium fluoride (SrF2) were fabricated in this study and subsequently delivered to breast cancer cells after incorporation with selected anticancer drugs. These treatment effectivities were assessed both in vitro using human and mice breast cancer cell lines, as well as in vivo using tumor-bearing mice models. Biodegradability, versatility, cost-effective and easy fabrication technique gives these nanocrystals marked advantages compared to other conventional nanoparticles.