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Delivering Micro-RNA (miRNA) via β-peptide Derived Biomaterial to Treat Ischemic Stroke

Version 2 2023-08-22, 01:06
Version 1 2023-08-15, 11:58
thesis
posted on 2023-08-22, 01:06 authored by YI-KAI CHEN
To address the challenges associated with miRNA therapy in ischemic stroke, including low in vivo stability and possible side effects, a delivery strategy is required for localised and controlled released of this gene-based therapeutic. This project focussed on utilising β-peptide derived materials to provide protection and sustained release to facilitate the therapeutic efficacy of miRNA in ischemic stroke.

History

Principal supervisor

Mark Pasqualino Del Borgo

Additional supervisor 1

Bradly Broughton

Additional supervisor 2

Mibel Aguilar

Year of Award

2023

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Pharmacology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

    Categories

    Keywords

    nanoparticlespeptide materialself-assembledcontrolled releasestroke treatmentmiRNA therapyinjectable hydrogel

    Licence

    In Copyright

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