Deletion of Cell Division Autoantigen 1 (CDA1) to Retard Diabetic Kidney Disease in db/db Diabetic Mice

Diabetic kidney disease, a leading cause of kidney failure, is a highly prevalent life-threatening complication in people with diabetes. This study focused on comprehensive characterisation of the pathological role of Cell Division Autoantigen 1 (CDA1) in diabetic kidney disease using a unique mouse model of type 2 diabetes. Indeed, genetic deletion of CDA1 was found to protect kidneys from diabetes-induced injury in this model. The findings, with novel mechanistic data from transcriptomic and proteomic analyses, validated CDA1 as a safe and efficacious therapeutic target to retard diabetic kidney disease, a promising approach to protect diabetic patients from kidney failure.