Monash University
Browse

File(s) under embargo

2

year(s)

2

day(s)

until file(s) become available

Defining the role of the revival stem cell during growth and therapy resistance in colorectal cancer

thesis
posted on 2023-06-22, 00:46 authored by SARA CAROLINE HLAVCA
Stem cells are found throughout the body where they produce new cells during regeneration or normal cellular turnover, and also produce more stem cells to ensure the stem cell pool is not depleted. However, under certain conditions, these stem cells may become cancerous and instead support tumour growth, therapy resistance and tumour relapse. A new stem cell population, called the revival stem cell, was recently identified in the normal mouse intestine. This thesis explores this new stem cell within human models of colorectal (or bowel) cancer, to investigate the role of the revival stem cell in a cancer context.

History

Principal supervisor

Helen Abud

Additional supervisor 1

Horace Chan

Additional supervisor 2

Rebekah Engel

Year of Award

2023

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Anatomy and Developmental Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

Usage metrics

    Faculty of Medicine, Nursing and Health Sciences Theses

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC