Embargoed and Restricted Access
Reason: Under embargo until 27 March 2027. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Defining the immunomodulatory effects of antisense oligonucleotides on TLR7 and TLR8
thesis
posted on 2024-03-26, 23:43 authored by ARWAF ALHARBIThis thesis investigates how certain chemically modified antisense oligonucleotides (ASOs), used in gene therapy, might unintentionally affect our immune system. Specifically, we looked at how these ASOs interact with Toll Like receptor (TLR) 7 and TLR8, which are important innate immune receptors involved in fighting infections. ASOs can suppress TLR7, while activating TLR8 response. Therefore, characterising such mmunomodulatory side effects on such important receptors is crucial to design safer and more effective ASOs treatments.
