L172 Submission thesis February 2018_Redacted.pdf (92.18 MB)
Download file

Defining Novel Targets and Biological Interventions in Human and Experimental Glomerulonephritis

Download (92.18 MB)
posted on 2019-03-27, 21:06 authored by KIM MAREE O'SULLIVAN
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV), is an autoimmune disease which causes inflammation of the small blood vessels of the kidney , which if left untreated causes glomerulonephritis. Current treatment does not address what causes the disease, it is toxic and can cause complications which contributes to death in patients suffering from AAV. The overall objective of this thesis was to contribute to the understanding of how AAV is caused at a cellular level, identify new potential therapeutic targets (in human tissue) and assess the benefits of two novel treatment strategies in experimental animal models of AAV.


Principal supervisor

Stephen Roger Holdsworth

Additional supervisor 1

Arthur Richard Kitching

Year of Award


Department, School or Centre

Medicine - Monash Health

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences