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Reason: Under embargo until 20 September 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library.
Deciphering the tripartite interactions among Acinetobacter baumannii - macrophage - polymyxin using a multi-omics approach
thesisposted on 2022-09-16, 21:32 authored by ZHI YING KHO
Bacterial response to antibiotics is sensitive to the surrounding environment. However, how the host innate immune cell affects the response of multidrug-resistant Acinetobacter baumannii towards the last-line polymyxins is largely unexplored, limiting optimisation of antibiotic therapy. In this PhD project, a tripartite in vitro model encompassing A. baumannii AB5075, human macrophages and polymyxin B was established; and a multi-omics approach was employed to decipher the complex molecular interplay and discover potential novel therapeutic targets. Several bacterial stress tolerance machineries in A. baumannii AB5075 were identified to be able to enhance the antibacterial killing by polymyxins. This project paves the way for discovery and development of novel antibacterial strategies.
Principal supervisorJian Li
Additional supervisor 1Mohammad A. K. Azad
Additional supervisor 2Mei-Ling Han
Year of Award2022
Department, School or CentreBiomedical Sciences (Monash Biomedicine Discovery Institute)
Additional Institution or OrganisationMicrobiology
CourseDoctor of Philosophy
FacultyFaculty of Medicine, Nursing and Health Sciences