File(s) under permanent embargo

Reason: Under embargo until September 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing document.delivery@monash.edu

Deciphering the tripartite interactions among Acinetobacter baumannii - macrophage - polymyxin using a multi-omics approach

thesis
posted on 16.09.2022, 21:32 authored by ZHI YING KHO
Bacterial response to antibiotics is sensitive to the surrounding environment. However, how the host innate immune cell affects the response of multidrug-resistant Acinetobacter baumannii towards the last-line polymyxins is largely unexplored, limiting optimisation of antibiotic therapy. In this PhD project, a tripartite in vitro model encompassing A. baumannii AB5075, human macrophages and polymyxin B was established; and a multi-omics approach was employed to decipher the complex molecular interplay and discover potential novel therapeutic targets. Several bacterial stress tolerance machineries in A. baumannii AB5075 were identified to be able to enhance the antibacterial killing by polymyxins. This project paves the way for discovery and development of novel antibacterial strategies.

History

Principal supervisor

Jian Li

Additional supervisor 1

Mohammad A. K. Azad

Additional supervisor 2

Mei-Ling Han

Year of Award

2022

Department, School or Centre

Microbiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences