DOES THE NOVEL GC ACTIVITY OF IRAK3 AFFECT ITS SIGNALLING?
thesisposted on 04.09.2017 by LUBNA FREIHAT
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A novel class of guanylate cyclases have recently been discovered that differ to classical guanylate cyclases. Guanylate cyclases are enzymes that catalyse the formation of cGMP, an important second messenger involved in countless biological processes. IRAK3 is an immune protein which functions to reduce the immune response, therefore acting as an anti-inflammatory protein. IRAK3 was shown to contain a guanylate cyclase centre, therefore it was hypothesised that IRAK3 may produce cGMP. The effect this novel guanylate cyclase centre has on the function of IRAK3 in the innate signalling cascade was investigated. This study demonstrates that the cGMP produced by the guanylate cyclase centre may function to modulate the function of IRAK3 and perhaps other proteins in its vicinity, therefore mediate the immune response.