Embargoed and Restricted Access
Reason: Under embargo until April 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
DEVELOPMENT OF STEREOSELECTIVE SYNTHESES OF BROMODOMAIN INHIBITORS AS ANTI-CANCER DRUGS
thesis
posted on 2018-04-16, 00:05 authored by MOHAMMAD AL AMINThis project explored the design, synthesis and testing of small molecules as anticancer agents. The compounds sought to block a particular family of (BET domain) proteins that affect cell growth. Specifically the research explored novel chemical scaffolds and required techniques to either synthesise or separate chiral substances. Encouragingly, these molecules were found to successfully block transcription pathways and represent an exciting new class of anticancer drugs that will be investigated further.
