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Reason: Under embargo until April 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

DEVELOPMENT OF STEREOSELECTIVE SYNTHESES OF BROMODOMAIN INHIBITORS AS ANTI-CANCER DRUGS

thesis
posted on 2018-04-16, 00:05 authored by MOHAMMAD AL AMIN
This project explored the design, synthesis and testing of small molecules as anticancer agents. The compounds sought to block a particular family of (BET domain) proteins that affect cell growth. Specifically the research explored novel chemical scaffolds and required techniques to either synthesise or separate chiral substances. Encouragingly, these molecules were found to successfully block transcription pathways and represent an exciting new class of anticancer drugs that will be investigated further.

History

Campus location

Australia

Principal supervisor

Philip Thompson

Additional supervisor 1

David Manallack

Year of Award

2018

Department, School or Centre

Medicinal Chemistry

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

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    Faculty of Pharmacy and Pharmaceutical Sciences Theses

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