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Reason: Under embargo until 2 May 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

DEM Simulation of Membrane Fouling and Cleaning in Virus/Protein Separation Process

thesis
posted on 2024-05-02, 00:31 authored by TING HU
The thesis simulates the purification process of IgG proteins from human plasma through Discrete Element Method (DEM) models. It develops models that are validated through experiment data of both symmetric and asymmetric membranes. Based on the validated models, the thesis investigates the fouling process in different stages, IgG/virus ratios captured inside the fouling region, interaction strength between solutes and membrane, and the cleaning efficiency under varying conditions. The work provides a new insight into enhancing biopharmaceutical safety and efficiency by understanding and mitigating membrane fouling, ensuring a longer membrane lifespan in critical medical processes.

History

Campus location

Australia

Principal supervisor

Huanting Wang

Additional supervisor 1

MARK MONROE BANASZAK HOLL

Additional supervisor 2

Xiwang Zhang

Additional supervisor 3

Qinfu Hou

Year of Award

2024

Department, School or Centre

Chemical & Biological Engineering

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Engineering

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