DEM Simulation of Membrane Fouling and Cleaning in Virus/Protein Separation Process

The thesis simulates the purification process of IgG proteins from human plasma through Discrete Element Method (DEM) models. It develops models that are validated through experiment data of both symmetric and asymmetric membranes. Based on the validated models, the thesis investigates the fouling process in different stages, IgG/virus ratios captured inside the fouling region, interaction strength between solutes and membrane, and the cleaning efficiency under varying conditions. The work provides a new insight into enhancing biopharmaceutical safety and efficiency by understanding and mitigating membrane fouling, ensuring a longer membrane lifespan in critical medical processes.