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Cyclodextrin mediated protection after diffuse traumatic brain injury

thesis
posted on 14.11.2019 by KATHERINE LOUISE GILLESPIE-JONES
Traumatic brain injury (TBI) is a major public health issue worldwide with those surviving the initial head injury experiencing long-lasting debilitating consequences. These injuries are commonly caused by car accidents, sporting field blows and falls in the general population; and exposure to explosive devices in military personnel. There is still no drug intervention available that reduces the long-term symptoms experienced by patients. In this thesis, we have shown for the first time in TBI, that a novel drug candidate cyclodextrin can markedly reduce brain dysfunction after injury, potentially through the modulation of cholesterol and maintenance of cerebral blood vessels.

History

Principal supervisor

Ramesh Rajan

Year of Award

2019

Department, School or Centre

Physiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Exports

Exports