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Cyclodextrin mediated protection after diffuse traumatic brain injury
thesisposted on 2019-11-14, 03:07 authored by KATHERINE LOUISE GILLESPIE-JONES
Traumatic brain injury (TBI) is a major public health issue worldwide with those surviving the initial head injury experiencing long-lasting debilitating consequences. These injuries are commonly caused by car accidents, sporting field blows and falls in the general population; and exposure to explosive devices in military personnel. There is still no drug intervention available that reduces the long-term symptoms experienced by patients. In this thesis, we have shown for the first time in TBI, that a novel drug candidate cyclodextrin can markedly reduce brain dysfunction after injury, potentially through the modulation of cholesterol and maintenance of cerebral blood vessels.