Monash University

Embargoed and Restricted Access

Reason: Under embargo until November 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Cyclodextrin mediated protection after diffuse traumatic brain injury

posted on 2019-11-14, 03:07 authored by KATHERINE LOUISE GILLESPIE-JONES
Traumatic brain injury (TBI) is a major public health issue worldwide with those surviving the initial head injury experiencing long-lasting debilitating consequences. These injuries are commonly caused by car accidents, sporting field blows and falls in the general population; and exposure to explosive devices in military personnel. There is still no drug intervention available that reduces the long-term symptoms experienced by patients. In this thesis, we have shown for the first time in TBI, that a novel drug candidate cyclodextrin can markedly reduce brain dysfunction after injury, potentially through the modulation of cholesterol and maintenance of cerebral blood vessels.


Principal supervisor

Ramesh Rajan

Year of Award


Department, School or Centre


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences