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Cyclic Peptides Targeting SPSB Proteins as Potential Anti-Infective Agents

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thesis
posted on 26.05.2019, 22:31 authored by MAIADA MOHSEN MOHAMED SADEK HASSAN
Inhibition of the interaction between SPRY domain containing SOCS Box Proteins (SPSB) and inducible nitric oxide synthase (iNOS) increases iNOS levels and cellular NO, and has been proposed to kill intracellular pathogens. Inhibitors of this interaction were discovered previously. However, they cannot penetrate live cells to reach their target proteins. Herein, several potent inhibitors (cyclic peptides and cell penetrating peptide conjugates) were generated. The conjugates were promising in penetrating the cell membrane, although more work need to be done to confirm this. Hence, this study act as a significant step towards the development of SPSB-iNOS inhibitors as potential anti-infective agents

History

Campus location

Australia

Principal supervisor

Raymond Norton

Year of Award

2019

Department, School or Centre

Medicinal Chemistry

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences